DPPH seeks to address the main privacy, security, scalability, and ethical challenges of data sharing for enabling effective P4 medicine, by defining an optimal balance between usability, scalability and data protection, and deploying an appropriate set of computing tools to make it happen. This main goal materializes in the following outcomes that the project expects to deliver: (i) A holistic requirements analysis of the medical data sharing ecosystem, from the standpoint of legal, ethical and medical stakeholders, (ii) a scalable scientific computing infrastructure, building on top of Swiss Data Science Center’s (SDSC) data science framework, (iii) software-based solutions for accountable and privacy-preserving data sharing featuring trust distribution across a federation of sites with no single points of failure, (iv) a quantitative analysis of inference risks, and countermeasures for addressing them when releasing aggregated results on patient data, and (v) a comprehensive ethical analysis of distributed platforms for medical data sharing.