In the case of advanced heart failure, the most efficient therapeutic intervention implies heart surgery with either a left ventricular assist device (LVAD) implantation or a cardiac transplantation (HTx). In the first case, a “coring” (i.e. removing) of the entire tissue of the apex of the heart in order to place the inflow cannula of the device is needed, thus providing a full thickness specimen of the diseased myocardium. For the regular follow-up of HTx patients (or for diagnosis), the established clinical practice is achieved via endomyocardial biopsies (EMB). The typical analysis procedure is done via histology in order to analyse the microstructure and to evaluate, for instance, the level of fibrosis in the cardiac tissue.