Advancing Precision Medicine with Integrated Multi-Omics Approaches
The Swiss Multi-Omics Center (SMOC) is a platform of the ETH Personalized Health and Related Technologies (PHRT) initiative that pioneers precision medicine by offering integrated multi-omics analysis of clinical samples. SMOC acts as a central hub, providing researchers and clinicians access to cutting-edge technologies and expert data interpretation to decipher the complex molecular basis of health and disease.
SMOC’s mission is to empower clinical research by generating molecular data, encompassing multiple omics layers, to facilitate a deeper understanding of disease mechanisms, enable biomarker discovery, targeted therapy development, and improved treatment response prediction. Capabilities of SMOC span genomics, transcriptomics, proteomics, and metabolomics. Services include ISO 15189-accredited Clinical Grade Sequencing, comprehensive quantitative and targeted proteomics, as well as targeted and untargeted metabolomics and lipidomics. SMOC is also developing computational algorithms and pipelines to extract meaningful insights from these vast multi-omics data collections. The mission of SMOC is further supported by strategic partnerships with the Swiss Personalized Health Network (SPHN), which advances ethical data infrastructure, and the Swiss Data Science Center (SDSC), which enhances predictive analytics across multi-dimensional datasets.
SMOC is actively involved in key research initiatives, including RAINDROP (Inborn Errors of Metabolism diagnosis), RAPIDS (pediatric sepsis diagnosis), and the tumor profiler. It contributes to the SwissPedHealth network’s pediatric research data stream and the “Genome of Switzerland” project, creating a national genomic reference dataset.
By facilitating access to advanced technologies and fostering collaboration, SMOC helps bridge the gap between research and clinical practice. It aims to ensure that multi-omics insights are both useful and practical for healthcare professionals thereby supporting a paradigm shift that tailors medical decisions to an individual’s unique molecular profile.