February 23, 2023

Platform for Metabolomics and Lipidomics

Platform, SMOC

Short Summary

The PHRT ETH Clinical Proteotype Analysis Center (CPAC), together with the PHRT ETH Clinical Metabolome Analysis Center (CMAC) and the PHRT EPFL Clinical Genome Analysis Center (CGAC), constitutes a central pillar of the PHRT/SPHN multi-omics strategy for precision medicine. Since their establishment, these centers have operated as an integrated infrastructure- the Swiss-Multi-Omics Center (SMOC)- enabling coordinated, high-quality multi-omics data generation from clinical biospecimens.

Goals

CPAC’s core objective is to deliver high-quality, standardized proteomics profiling of clinical cohorts and to integrate the generated data with complementary omics layers. This allows systems-level characterization of disease and supports the translation of molecular insights into clinically actionable information.

Significance

The Swiss Multi-Omics Center represents a critical infrastructure for advancing precision medicine in Switzerland. Within SMOC, CPAC provides the functional molecular layer required to interpret disease biology and contributes to the development of data-driven, mechanism-informed healthcare strategies.

Background

Proteomics provides a direct functional readout of biological processes and is essential for linking molecular variation to phenotype. CPAC provides the expertise, technologies, and standardized workflows necessary to enable high-quality poteomics within integrated multi-omics studies.

Publications

A Delabriere, P Warmer, V Brennsteiner, N Zamboni, SLAW: A scalable and self-optimizing processing workflow for untargeted LC-MS, Anal. Chem. 2021, 93, 45, 15024–15032
A Dmitrenko, M Rei, Ni Zamboni1, A system suitability testing platform for untargeted, high-resolution mass spectrometry, Front. Mol. Biosci., 11 October 2022
A Egli, M Battegay, AC Büchler, P Bühlmann, T Calandra, P Eckert, et al. SPHN/PHRT: forming a Swiss-wide infrastructure for data-driven sepsis research, Studies in health technology and informatics 270, 1163-1167
BW van der Kolk, S Saari, A Lovric, M Arif, M Alvarez, A Ko, Z Miao, et al. Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI, Cell Reports Medicine 2 (4), 100226
MA Stravs, K Dührkop, S Böcker, N Zamboni, MSNovelist: De novo structure generation from mass spectra, Nat Methods 19, 865–870 (2022).